Describe how the mammalian body protects itself against infections. (20m)

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Pathogenic microbes are found on the skin, respiratory tract, mouth, vagina and the intestinal tract; the skin; has a keratinised and waterproof cornified outer layer; that provides a mechanical barrier to microbes/prevents entry of microbes; sebaceous gland; produces sebum; which has antiseptic properties; the respiratory tract; produce mucus secretions that trap dust; cilia sweep/waft/propel the microbes to the pharynx for swallowing or to be coughed out; reflex actions of coughing/sneezing/vomiting help remove foreign materials from the respiratory tract/digestive tract; lysozymes/enzymes in saliva/nasal secretions/tears; digest walls of bacteria destroying them; gastric secretions such as hydrochloric acid lowers the pH in the stomach killing micro-organisms; clotting of blood; prevents entry of microbes after damage of blood vessels; phagocytosis; by phagocytes engulf and destroy microbes and other foreign bodies; lymphocytes are stimulated to produce antibodies; by proteins present in microbes protecting the body; antibodies destroy/kill micro-organisms through various ways: agglutinins; bind to pathogens making them clump together; killing them; Lysins; bind to pathogens and make them burst or disintegrate; opsonins; bind to pathogens making them easily recognized hence be engulfed/destroyed by other lymphocytes; anti-toxins; bind and neutralize toxins produced by micro-organisms; vagina is acidic; hence making it not conducive for growth and reproduction of micro-organisms; Max: 20 mks

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